METHODS FOR MEASURING CELL RESPONSE TO DNA DAMAGING AGENTS USING PROMYELOCYTIC LEUKEMIA PROTEIN NUCLEAR BODIES

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United States of America Patent

APP PUB NO 20100248226A1
SERIAL NO

12376432

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Abstract

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Methods for assessing the potential efficacy of a DNA-damaging agent as a tumour treatment or for monitoring the efficacy of such treatment by determining promyelocytic leukemia protein nuclear body (PML NB) properties of the tumour are disclosed. PML NB properties, including morphology, number and biochemical composition, of cells or tissue are assessed following exposure to a DNA-damaging agent and compared to corresponding PML NB properties of cells or tissue not exposed to the DNA-damaging agent. The difference, or lack thereof, determines the efficacy of the DNA-damaging agent as a treatment for tumours or monitoring the efficacy of such treatment.

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Patent Owner(s)

Patent OwnerAddress
DALHOUSIE UNIVERSITY1344 SUMMER STREET SUITE 207 HALIFAX NOVA SCOTIA B3H 4R2

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  • 2007 Application Filing Year
  • C12Q Class
  • 2384 Applications Filed
  • 1112 Patents Issued To-Date
  • 46.65 % Issued To-Date
Click to zoom InYear of Issuance% of Matters IssuedCumulative IssuancesYearly Issuances200720082009201020112012201320142015201620172018201920200255075100

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bazett-Jones, David Toronto, CA 1 0
Dellaire, Graham Halifax, CA 3 3

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