POLYPEPTIDES, ANTIBODY VARIABLE DOMAINS AND ANTAGONISTS
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United States of America Patent
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Issued Date -
Sep 30, 2010
app pub date -
Jun 4, 2008
filing date -
Jun 6, 2007
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Abstract
The invention relates to anti-VEGF polypeptides and antibody single variable domains (dAbs) that are resistant to degradation by a protease, as well as antagonists comprising these. The polypeptides, dAbs and antagonists are useful for pulmonary administration, oral administration, delivery to the lung and delivery to the GI tract of a patient, as well as for treating cancer and inflammatory disease, such as arthritis.
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