THE FUNCTIONAL EPITOPE OF OSTEOPONTIN, THE ANTI-OSTEOPONTIN MONOCLONAL ANTIBODY AND USE THEREOF
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United States of America Patent
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Issued Date -
Sep 23, 2010
app pub date -
Mar 25, 2008
filing date -
Apr 24, 2007
priority date (Note) -
Abandoned
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Abstract
The present invention discloses the functional epitope of osteopontin; the anti-osteopontin monoclonal antibody and immune conjugate raising against the functional epitope and their use for preparing anti-tumor drug. The present invention also discloses the DNA sequence encoding the monoclonal antibody, the vector and host cell containing the DNA sequence. The monoclonal antibody and immune conjugate of present invention can also be used to detect OPN. Through inhibiting OPN, the monoclonal antibody or immune conjugate of present invention can remedy or respite autoimmune diseases and protect correlative tissues, so they can be used to remedy autoimmune diseases.
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