Method for Identifying Modulators of Gamma Secretase or Notch
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United States of America Patent
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Issued Date -
Sep 16, 2010
app pub date -
Sep 1, 2006
filing date -
Sep 7, 2005
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Abstract
The present invention relates to methods for high throughput screening to identify selective modulators of γ-secretase. Such modulators selectively block γ-secretase activity without affecting Notch cleavage and signaling. Said methods employ the use of high content screening methodologies to measure and quantify the translocation of the Notch intracellular domain (NICD) between the nucleus and cytoplasm in cells and the activation of Notch.
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