COMPOSITIONS AND METHODS FOR POTENTIATING ANTIBIOTIC ACTIVITY
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United States of America Patent
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Issued Date -
Sep 16, 2010
app pub date -
Aug 2, 2007
filing date -
Aug 4, 2006
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Abandoned
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Abstract
The present invention provides compounds that potentiate the activity of antibiotic agents, particularly quinolones such as norflaxin. The invention further provides compositions, e.g., pharmaceutical compositions, comprising the inventive compounds. The invention also provides compositions comprising an antibiotic (e.g., a quinolone) and a compound that potentiates activity of the antibiotic. The invention further provides methods of treating a subject comprising administering any of the inventive compounds or compositions to the subject. The invention also provides screening methods to identify compounds that potentiate the activity of an antibiotic, e.g., a quinolone.
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