Method For Generating and Selecting Antibodies Against Target Protein
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United States of America Patent
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app pub date -
Feb 26, 2010
filing date -
Feb 8, 2002
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Abstract
Compositions are provided that comprise antibody against membrane proteins such as chemokine receptors. In particular, monoclonal human antibodies against human CXCR4 are provided that are capable of inhibiting HIV infection and chemotaxis in human breast cancer cells. The antibodies can be used as prophylactics or therapeutics to prevent and treat HIV infection and cancer, for screening drugs, and for diagnosing diseases or conditions associated with interactions with chemokine receptors.
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