POLYSIALIC ACID DERIVATIVES
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United States of America Patent
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Mar 3, 2010
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Aug 12, 2003
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Abstract
A polysialic acid compound is reacted with a hetero-bifunctional reagent to introduce a pendant functional group for site-specific conjugation to sulfhydryl groups, for instance side chains of cysteine units in drugs, drug delivery systems, proteins or peptides. The functional group is, for instance, an N-maleimide group.
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