METHODS OF IDENTIFYING AND USING SNAIL1 INHIBITORY COMPOUNDS IN CHONDRODYSPLASIA TREATMENT AND PREPARATION OF PHARMACEUTICAL COMPOSITIONS
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United States of America Patent
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Issued Date -
Aug 26, 2010
app pub date -
Mar 7, 2008
filing date -
Mar 8, 2007
priority date (Note) -
Abandoned
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Abstract
Exemplary embodiments disclosed herein demonstrate that the Snail1 gene contributes to FGFR3 receptor signal transduction, which contributes to chondrodysplasias (achondroplasia (ACH), thanatophoric dysplasia (TD) and hypochondroplasia (HCH)). The exemplary embodiments identify Snail1 as a therapeutic and diagnostic target for chondrodysplasia, as well as the use of inhibitors thereof as drugs for the treatment of these diseases.
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- A61K:PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOS....
- C07H:SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTI....
- C12Q:MEASURING OR TESTING PROCESSES INVOLVING ENZYMES O....
- G01N:INVESTIGATING OR ANALYSING MATERIALS BY DETERMININ....
- A01K:ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; ....
- A61P:THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDI....
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