Synthesis of spongosine
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United States of America Patent
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Issued Date -
Aug 26, 2010
app pub date -
Jan 19, 2005
filing date -
Jan 21, 2004
priority date (Note) -
Abandoned
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Abstract
Reaction of 1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose with 2-methoxyadenine to form 9-(2′,3′,5′-tri-O-benzoyl-β-D-ribofuranosyl)-2-methoxyadenine, then deprotection of the 9-(2′,3′,5′-tri-O-benzoyl-β-D-ribofuranosyl)-2-methoxyadenine to form spongosine is described. Synthesis of intermediates for use in the synthesis of spongosine is also described.
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