Process For The Preparation of 7 alpha-Methylsteroids

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United States of America Patent

SERIAL NO

12765629

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Abstract

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The invention relates to a process for the preparation of 7α-methyl hydroxy steroids of the formula IMgX, X being a halogen, to the 4,6-unsaturated 3-ketosteroid of formula II,comprising protecting the hydroxy group of the steroid of formula II with a trialkylsilyl group, followed by treating the hydroxy protected steroid with the Grignard reagent.The process of the invention is useful for the production of pharmacologically interesting steroids.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ostendorf, Martin Oss, NL 5 1
Stoelwinder, Johannes Oss, NL 4 1
Van, Buggenum Patrick Arnoldus Maria Oss, NL 2 1

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