PRODUCTION OF HIGH MANNOSE PROTEINS IN PLANT CULTURE

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United States of America Patent

SERIAL NO

12451188

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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A device, system and method for producing glycosylated proteins in plant culture, particularly proteins having a high mannose glycosylation, while targeting such proteins with an ER signal and/or by-passing the Golgi. The invention further relates to vectors and methods for expression and production of enzymatically active high mannose lysosomal enzymes using transgenic plant root, particularly carrot cells. More particularly, the invention relates to host cells, particularly transgenic suspended carrot cells, vectors and methods for high yield expression and production of biologically active high mannose Glucocerebrosidase (GCD). The invention further provides for compositions and methods for the treatment of lysosomal storage diseases.

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Patent Owner(s)

Patent OwnerAddress
PROTALIX LTDCARMIEL

International Classification(s)

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  • 2008 Application Filing Year
  • A61K Class
  • 9711 Applications Filed
  • 5862 Patents Issued To-Date
  • 60.37 % Issued To-Date
Click to zoom InYear of Issuance% of Matters IssuedCumulative IssuancesYearly Issuances200820092010201120122013201420152016201720182019202020212022202320240255075100

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bartfeld, Daniel Moran- Doar-Na Bikat Beit HaKerem, IL 19 188
Baum, Gideon D.N. Upper Galilee, IL 16 178
Hashmueli, Sharon Ramot-Naftali, IL 13 141
Lewkowicz, Ayala Kfar-Vradim, IL 14 125
Shaaltiel, Yoseph Kibbutz HaSolelim-Doar-Na HaMovil, IL 43 445

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Patent Citation Ranking

  • 2 Citation Count
  • A61K Class
  • 11.97 % this patent is cited more than
  • 15 Age
Citation count rangeNumber of patents cited in rangeNumber of patents cited in various citation count ranges7303334104243222310478582826113401 - 1011 - 2021 - 3031 - 4041 - 5051 - 6061 - 7071 - 8081 - 9091 - 100100 +020040060080010001200140016001800200022002400260028003000320034003600

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