ANTICANCER PRODRUG SENSITIVE TO TARGET PROTEASE
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United States of America Patent
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Issued Date -
Jul 22, 2010
app pub date -
Jan 19, 2009
filing date -
Jan 14, 2009
priority date (Note) -
Abandoned
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Abstract
Provided is an anticancer prodrug sensitive to a target protease. The anticancer prodrug includes an anticancer drug, peptide that is specifically decomposed by the target protease excessively secreted by cancer cells, and a polymer that is specifically accumulated at a target cancer site. When the inactive anticancer prodrug is administered, the anticancer prodrug is accumulated at the target caner site and then the peptide is decomposed by irradiation of radioactive rays, thereby releasing an active anticancer drug at the target caner site. Accordingly, destruction of normal cells can be minimized and a high anticancer therapeutic effect can be obtained by using a small amount of the anticancer drug administered and a small amount of radioactive rays irradiated.
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