Stable vaccine compositions and methods of use
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United States of America Patent
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Issued Date -
Jul 22, 2010
app pub date -
Jan 22, 2009
filing date -
Jan 22, 2009
priority date (Note) -
Abandoned
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Abstract
A stable lyophilized protein formulation containing recombinant Protective Antigen (rPA) is described that can be reconstituted with a suitable diluent to generate a high potency protein concentration reconstituted formulation which is suitable for use as a vaccine against anthrax infection in mammals, especially human beings. These formulations were prepared by lyophilizing rPA in the presence of a reducing sugar, such as trehalose, and methods of such lyophilization are described. The resulting lyophilized mixture or composition is subsequently reconstituted to high immunogenicity without apparent loss of stability of the rPA protein. Methods of using said formulations in vaccination are also described.
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