DENTINOGENESIS PROMOTER AND DENTINOGENIC PULP-CAPPING MATERIAL

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United States of America Patent

APP PUB NO 20100183563A1
SERIAL NO

12593763

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention provides a dentinogenesis inducer and dentinogenesis pulp-capping material, which are effectively used for formation (regeneration) of dentin. The present invention also provides a method of producing odontoblasts useful for dental regenerative therapy and the application of the obtained odontoblasts. The dentinogenesis inducer and the dentinogenesis pulp-capping material of the present invention are both characterized by the use of an HMG-CoA reductase inhibitor as an active ingredient. Additionally, odontoblasts can be produced by culturing cells capable of differentiating into odontoblasts in the presence of the HMG-CoA reductase inhibitor.

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Patent Owner(s)

Patent OwnerAddress
NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY1-1 TSUSHIMA-NAKA 1-CHOME OKAYAMA-SHI OKAYAMA 770-8530

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Fujisawa, Takuo Okayama, JP 2 7
Kuboki, Takuo Okayama, JP 3 7
Okamoto, Yosuke Okayama, JP 28 159
Ono, Mitsuaki Okayama, JP 4 24
Oshima, Masamitsu Okayama, JP 8 74
Shimono, Kengo Okayama, JP 1 6
Sonoyama, Wataru Okayama, JP 3 15

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