VECTOR CONSTRUCTS AND METHODS FOR EXPRESSING AND SECRETING POLYPEPTIDES IN FILAMENTOUS FUNGI USING A SELF-PROCESSING 2A CLEAVAGE SITE
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United States of America Patent
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Issued Date -
Jul 15, 2010
app pub date -
Jul 19, 2007
filing date -
Jul 24, 2006
priority date (Note) -
Abandoned
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Abstract
The invention relates to a vector construct for expressing and secreting polypeptides in filamentous fungi, comprising, in 5'3' direction, in functional linkage, optionally a promoter which may have an enhancer placed upstream, at least one DNA sequence which codes for a first polypeptide and which may comprise a signal sequence or not, optionally a DNA sequence which codes for a 2A cleavage site or for a sequence derived therefrom, optionally together with an upstream DNA sequence which codes for a proteolytic cleavage site, or optionally a DNA sequence which codes for a proteolytic cleavage site, a DNA sequence which codes for a second polypeptide with signal sequence, optionally a further DNA sequence which codes for a 2A cleavage site or for a sequence derived therefrom, optionally together with an upstream DNA sequence which codes for a proteolytic cleavage site, or optionally a DNA sequence which codes for a proteolytic cleavage site, optionally a DNA sequence which codes for a third polypeptide with signal sequence, optionally a further DNA sequence which codes for a 2A cleavage site or for a sequence derived therefrom, optionally together with an upstream DNA sequence which codes for a proteolytic cleavage site, or optionally a DNA sequence which codes for a proteolytic cleavage site, optionally a DNA sequence which codes for a fourth polypeptide with signal sequence, a terminator,where at least one 2A cleavage site or a sequence derived therefrom is present in the construct.
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