INHIBITION OF GENE EXPRESSION
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United States of America Patent
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Issued Date -
Jul 8, 2010
app pub date -
Jan 30, 2008
filing date -
Jan 30, 2007
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Abandoned
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Abstract
There is provided a method of inhibiting gene expression by locating a 5′-5 donor splicing site sequence in the 3′ UTR of a gene or within coding sequence containing the stop codon of a gene. Stability of homologous mRNA in trans is also adversely affected leading to a reduction in expression. A polynucleotide containing a 5′-donor splicing site sequence in either coding sequence containing the stop codon or the 3′ UTR is also provided and in one embodiment is in the form of a vector. The 5′-donor splicing site sequence can be present in multiple copies, for example as a tandem repeat. In one embodiment the 5-donor splicing site sequence has the sequence 5′-MAGGTRAGTA-3′ where M is A or C and R is A or G.
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