OXINDOLE HYDRAZIDE MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS)
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United States of America Patent
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N/A
Issued Date -
N/A
app pub date -
Dec 23, 2009
filing date -
Oct 30, 2001
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
The present invention is related to the use of oxindole hydrazide derivatives of formula (I) for the treatment and/or prevention of metabolic disorders mediated by insulin resistance or hyperglycemia, comprising diabetes type I and/or II, inadequate glucose tolerance, insulin resistance, hyperlipidemia, hypertriglyceridemia, hypercholesterolemia, obesity, polycystic ovary syndrome (PCOS). In particular, the present invention is related to the use of oxindole hydrazide derivatives of formula (I) to modulate, notably to inhibit the activity of PTPs, in particular of PTP1B, TC-PTP, SHP and GLEPP-1. The present invention is furthermore related to novel oxindole hydrazide derivatives and method of preparation thereof.
First Claim
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Family
| Country | kind | publication No. | Filing Date |
|---|---|---|---|
| JP | B2 | JP4846978 | Oct 24, 2002 |
| AU | B2 | AU2002342859 | Oct 24, 2002 |
| IL | A0 | IL161582 | Oct 24, 2002 |
| CA | C | CA2463615 | Oct 24, 2002 |
| EP | A1 | EP1439834 | Oct 24, 2002 |
| WO | A1 | WO2003037328 | Oct 24, 2002 |
| US | B2 | US7696231 | Oct 05, 2004 |
International Classification(s)
Cited Art Landscape
Patent Citation Ranking
- 3 Citation Count
- A61K Class
- 11.97 % this patent is cited more than
- 15 Age