METHOD OF GENERATING REGULATORY T CELLS USING CORD BLOOD AND ADULT BLOOD CD14+ MONOCYTE CELLS
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United States of America Patent
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Issued Date -
Jul 1, 2010
app pub date -
Dec 22, 2009
filing date -
Dec 29, 2008
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Abandoned
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Abstract
A method of inducing stable and functional Tregs from human umbilical cord blood and adult blood without requiring the expansion of pre-existing Tregs. The method utilizes CD14+ monocyte cells present in or isolated from cord blood or adult blood to induce functional Tregs from T cells, and particularly T cells that express CD4+, which may also be obtained from cord blood or adult blood. The developed Tregs are long-lasting and maintain their suppressive functions.
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