Novel Oligonucleotide and NF-kB Decoy Comprising the Same
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United States of America Patent
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Issued Date -
Jul 1, 2010
app pub date -
Dec 21, 2006
filing date -
Dec 22, 2005
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Abstract
A novel oligonucleotide useful as an NF-κB decoy having a higher binding ability to NF-κB than known NF-κB decoy as well as the medical uses thereof, is disclosed. The oligonucleotide of the invention has a base sequence having a consensus sequence and specific 5′-flanking and 3′-flanking sequences ligated to both ends of the consensus sequence, respectively. The NF-κB decoy is constituted by an oligonucleotide which is the above-described oligonucleotide of the invention and which is substantially double-stranded wherein the strands are complementary to each other.
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