Method and System for Detecting Peptide Peaks in HPLC-MS Signals
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United States of America Patent
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Issued Date -
Jun 24, 2010
app pub date -
May 30, 2008
filing date -
May 31, 2007
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Abstract
The present invention relates to a method, a computer tool and a system for detecting peptide peaks in measurement signals (11) generated by HPLC-MS instruments. The method comprises the steps of: providing an intensity column vector (SIC) representative of the elution values at a specific mass value (m/z) of the measurement signal (11); cam. performing a wavelet decomposition (15) of such values of said intensity column vector (SIC) to generate a first processed vector (16) representative of the smoothed intensity values of the intensity column vector (SIC); providing a threshold value (S) and performing a wavelet decomposition (17) as a function of the value of said threshold (S) to generate the second processed vector (18) representative of said intensity column vector (SIC) cleaned of any oscillations generated by stochastic noise (e(t)); processing said first processed vector (16) and said second processed vector (18) to generate a third processed vector (19) identifying the baseline values of said intensity column vector (SIC); processing said intensity column vector (SIC) and said second (18) and third (19) vectors to generate e filtered vector (20) identifying any peak value (ZJ) below the background noise (12).
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