INDUSTRIAL PROCESS FOR PREPARATION OF CLOPIDOGREL HYDROGEN SULPHATE

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United States of America Patent

SERIAL NO

12607714

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Abstract

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An improved process for the manufacture of Clopidogrel starting from 2-(2-thienyl)ethylamine, which eliminates the isolation of an unstable intermediate like 2-(2-thienyl)ethyl formimine by subjecting it to a one pot cyclization to get 4,5,6,7-tetrahydrothieno (3,2-c) pyridine of Formula II and further reacting with halo-compound of formula III (where X is Cl or Br) at 20 to 90° C. temperature characterized in a solvent like water and/or dichloroethane in presence of organic or inorganic bases is disclosed herein. This inventions also discloses Crystalline Form I of (+)-(S)-clopidogrel hydrogen sulphate and its preparation thereof.

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IPCA LABORATORIES LTD48 KANDIVLI INDUSTRIAL ESTATE MUMBAI-400 067

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Barve, Sanjay Govind Maharashtra, IN 3 8
Bhayani, Priti Jayesh Maharashtra, IN 4 1
Burudkar, Sandeep Madhavrao Maharashtra, IN 3 1
Kumar, Ashok Mumbai, IN 191 1710
Kushwaha, Lavkesh Dayashankar Maharashtra, IN 3 8
Nandavadekar, Sanjay Maharashtra, IN 2 1
Shah, Chirag Hasmukh Maharashtra, IN 4 1
Vyas, Ketan Dhansukhlal Maharashtra, IN 4 1

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