4-oxo-4,5-dihydropyrrolo[1,2-A)quinoxaline derivatives as inhibitors of poly(ADP-ribose) polymerase (PARP)

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United States of America Patent

APP PUB NO 20100152180A1
SERIAL NO

12376613

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Abstract

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The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of poly(ADP-ribose)polymerase (PARP) and thus useful for the treatment of cancer, inflammatory diseases, reperfusion injuries, ischaemic conditions, stroke, renal failure, cardiovascular diseases, vascular diseases other than cardiovascular diseases, diabetes mellitus, neurodegenerative diseases, retroviral infections, retinal damage, skin senescence and UV-induced skin damage, and as chemo- or radiosensitizers for cancer treatment.

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Patent Owner(s)

Patent OwnerAddress
ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P ANGELETTI SPAVIA PONTINA KM 30 600 00040 POMEZIA (ROME)

International Classification(s)

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  • 2007 Application Filing Year
  • A61K Class
  • 9805 Applications Filed
  • 5595 Patents Issued To-Date
  • 57.07 % Issued To-Date
Click to zoom InYear of Issuance% of Matters IssuedCumulative IssuancesYearly Issuances2007200820092010201120122013201420152016201720182019202020212022202320240255075100

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Jones, Philip Rome, IT 185 1433
Koch, Uwe Rome, IT 66 551
Ontoria, Ontoria Jesus Maria Rome, IT 20 175
Scarpelli, Rita Rome, IT 28 220
Schultz-Fademrecht, Carsten Oss, NL 23 214

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Citation count rangeNumber of patents cited in rangeNumber of patents cited in various citation count ranges7303334104243222310478582826113401 - 1011 - 2021 - 3031 - 4041 - 5051 - 6061 - 7071 - 8081 - 9091 - 100100 +020040060080010001200140016001800200022002400260028003000320034003600

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