Formulations for Delivery Via Pressurised Metered Dose Inhalers Comprising an Essential Oil as Suspension Stabiliser
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Issued Date -
Jun 10, 2010
app pub date -
Oct 31, 2007
filing date -
Oct 31, 2006
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Abstract
A formulation suitable for delivery from a pressurised metered dose inhaler comprises a hydrofluoroalkane liquid, which is pharmaceutically acceptable, for instance HFA 134a or HFA 227, a drug to be delivered to the lung which is insoluble in the hydrofluoroalkane, the drug being in particulate form in the composition, further containing a suspension stabiliser which is a non-toxic essential oil miscible with the hydrofluoroalkane liquid at room temperature. The essential oil is preferably one having some amphiphilic property, such as a ketone or aldehyde compound. Insulin may be formulated for inhalation.
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