METHOD FOR MODULATING THE IMMUNE RESPONSE BY ACTIVATING OR INACTIVATING THE NOTCH AND/OR STAT4 SIGNAL PATH
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United States of America Patent
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Issued Date -
Jun 3, 2010
app pub date -
Jan 30, 2008
filing date -
Jan 30, 2007
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Abstract
The invention relates to a method for modulating the inflammatory potential of T cells, in particular by regulating the IL-10 production in pro-inflammatory T cells, by influencing the activity or activation of the Notch and STAT4 signaling pathways. The invention also relates to the use of the method for inhibiting inflammations or in immunosuppression. More specifically, the invention relates to the use of the method in the treatment of diseases associated with inflammations. Furthermore, the invention relates to the use of the method for reducing the IL-10 production in pro-inflammatory T cells and thus the enhancement of T cell-mediated immune reaction, especially in the event of infections, tumor diseases or vaccinations against infections or tumors.
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