USE OF PAX4 IN PANCREATIC CELL PROLIFERATION
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United States of America Patent
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Issued Date -
Jun 3, 2010
app pub date -
Aug 9, 2005
filing date -
Aug 11, 2004
priority date (Note) -
Abandoned
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Abstract
The present invention relates to an in vitro method for the generation and isolation of pancreatic β-cells, comprising the steps of (a) contacting an adult cell derived from mammalian pancreatic islets or an explant culture of adult pancreatic islets with functional, wild-type Pax4; and (b) detecting and isolating; from said adult cell or explant culture, β-cells that proliferate in response to the contact with Pax4. Furthermore, the use of functional; wild-type Pax4 for the preparation of a pharmaceutical composition for transplantation and/or tissue replacement is described.
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