PROCESS FOR PREPARATION OF RISPERIDONE
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United States of America Patent
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Issued Date -
May 27, 2010
app pub date -
Jul 25, 2008
filing date -
Jul 26, 2007
priority date (Note) -
Abandoned
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Abstract
The invention provides a more handy and environment friendly process for preparing risperidone, which comprises reacting 6-fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride with 3-(2-chloroethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one in a basic aqueous solution or suspension. The concentration of alkaline metal carbonates in the basic aqueous solution or suspension is ranged from 15% to 40%. The reaction is carried out at a temperature range of 101-140° C. and the reaction is completed within 10 minutes to 2 hours.
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