LIPOSOME DRUG CARRIERS WITH PH-SENSITIVITY

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United States of America Patent

APP PUB NO 20100129430A1
SERIAL NO

12276696

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Using liposomes to deliver bioactive agents to cancer or tumor cells and compositions of specific lipids that form liposomes to deliver a biologically active agent. A liposome composition for delivering of a biologically active agent, comprising liposomes comprising at a least first rigid lipid and a second rigid lipid each having a head group and a hydrophobic tail; a polyethyleneglycol-linked lipid having a side chain matching at least a portion of the first or the second lipid; and an entrapped biologically active agent. The first lipid can be a zwitterionic lipid and the second lipid can have a titratable head group. The composition can be adapted to release the entrapped at a certain pH.

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Patent Owner(s)

Patent OwnerAddress
POLYTECHNIC UNIVERSITYSIX METRO TECH CENTER BROOKLYN NY 11201

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Sofou, Stavroula Brooklyn, US 6 12

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