CELLS EXPRESSING ALPHA-SYNUCLEIN AND USES THEREFOR
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May 13, 2010
app pub date -
Oct 12, 2007
filing date -
Oct 13, 2006
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Abstract
Disclosed are mammalian neuronal cells expressing alpha synuclein as well as methods of screening to identify compounds that decrease toxicity induced by alpha synuclein expression. Compounds identified by such screens can be used to treat or prevent synucleinopathies such as Parkinson's disease, familial Parkinson's disease, Lewy body disease, the Lewy body variant of Alzheimer's disease, dementia with Lewy bodies, multiple system atrophy, or the Parkinsonism-dementia complex of Guam.
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