MACROCYCLIC HEPATITIS C SERINE PROTEASE INHIBITORS AND USES THEREFOR
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United States of America Patent
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Issued Date -
May 13, 2010
app pub date -
Dec 5, 2007
filing date -
Dec 6, 2006
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Abandoned
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Abstract
Macrocyclic inhibitors of Hepatitis C protease are provided, the inhibitors including a boronic acid or ester group, a macrocyclic ring of about 13 to 25 atoms including at least two amide linkages, a proline-analogous group, and a connecting segment joining moieties on either side of the proline-analogous group. Methods of making the HCV protease-inhibitory compounds, methods of using the compounds, formulations of the compounds, and pharmaceutical combinations including the compounds, are provided.
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