COMPOSITIONS COMPRISING (S)-2-AMINO-1-(4-CHLOROPHENYL)-1-[4-(1H-PYRAZOL-4-YL)-PHENYL]-ETHANOL AS MODULATOR OF PROTEIN KINASES

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United States of America Patent

APP PUB NO 20100113551A1
SERIAL NO

12531013

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Abstract

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The invention provides a composition comprising (S) 2-amino-1-(4-chloro-phenyl)-1-[4-(1H-pyrazol-4-yl)-phenyl]-ethanol, wherein the composition is either substantially free of (R) 2-amino-1-(4-chloro-phenyl)-1-[4-(1H-pyrazol-4-yl)-phenyl]-ethanol or the composition contains a mixture of the (S) and (R) enantiomers in which the (S) enantiomer predominates. Also provided are processes for the preparation of the (S) 2-amino-1-(4-chloro-phenyl)-1-[4-(1H-pyrazol-4-yl)-phenyl]-ethanol, novel process intermediates and methods for making the novel process intermediates.

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Patent Owner(s)

Patent OwnerAddress
CANCER RESEARCH TECHNOLOGY LIMITEDANGEL BUILDING 407 ST JOHN STREET LONDON EC1V4AD
ASTEX THERAPEUTICS LIMITEDCAMBRIDGE CAMBRIDGESHIRE CB4 0QA
THE INSTITUTE OF CANCER RESEARCH ROYAL CANCER HOSPITAL123 OLD BROMPTON ROAD LONDON SW7 3RP

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Frederickson, Martyn Cambridge, GB 28 259
Grimshaw, Kyla Merriom Cambridge, GB 3 19
Rees, David Charles Cambridge, GB 28 352
Woodhead, Steven John Cambridge, GB 32 655

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