Evaluating RTK Target Drugs
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United States of America Patent
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Issued Date -
May 6, 2010
app pub date -
Mar 7, 2008
filing date -
Mar 20, 2007
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Abandoned
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Abstract
Methods of evaluating receptor tyrosine kinase drug efficacy are demonstrated. The methods generally relate to evaluation methods using phospho-RTK over total RTK ratio (pRTK/tRTK). An algorithm is provided that allows the user to combine the pRTK/tRTK ratios from several kinase together with other kinds of measurements to obtain a PDX value that is indicative of drug efficacy.
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