BRAIN-LOCALIZING POLYPEPTIDES COMPRISING A MULTIVALENT BINDING MOIETY AND IMPROVED METABOLIC STABILITY

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United States of America Patent

APP PUB NO 20100111838A1
SERIAL NO

12449982

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Brain-localizing polypeptides carrying a reactive group for linking to a molecule that does not have brain-localizing activity were successfully produced by introducing at least two lysine residues into cyclized polypeptides having a brain-localizing motif sequence. These polypeptides have improved metabolic stability compared to conventional brain-localizing polypeptides, and can efficiently translocate desired molecules into the brain.

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Patent Owner(s)

Patent OwnerAddress
ACTGEN INC15-502 AKAHO KOMAGANE-SHI NAGANO

International Classification(s)

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  • 2008 Application Filing Year
  • A61K Class
  • 9711 Applications Filed
  • 5862 Patents Issued To-Date
  • 60.37 % Issued To-Date
Click to zoom InYear of Issuance% of Matters IssuedCumulative IssuancesYearly Issuances200820092010201120122013201420152016201720182019202020212022202320240255075100

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hara, Hirotaka Aichi, JP 41 373
Haradahira, Terushi Chiba, JP 4 64
Higuchi, Makoto Chiba, JP 30 84
Ki, Hin Chiba, JP 1 1
Nakajo, Tomohiro Saitama, JP 1 1
Sawada, Makoto Aichi, JP 109 555
Suhara, Tetsuya Chiba, JP 17 23
Suzuki, Hiromi Aichi, JP 62 936
Yamamoto, Kazumasa Aichi, JP 18 241

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  • 1 Citation Count
  • A61K Class
  • 11.97 % this patent is cited more than
  • 15 Age
Citation count rangeNumber of patents cited in rangeNumber of patents cited in various citation count ranges7303334104243222310478582826113401 - 1011 - 2021 - 3031 - 4041 - 5051 - 6061 - 7071 - 8081 - 9091 - 100100 +020040060080010001200140016001800200022002400260028003000320034003600

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