BRAIN-LOCALIZING POLYPEPTIDES COMPRISING A MULTIVALENT BINDING MOIETY AND IMPROVED METABOLIC STABILITY
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United States of America Patent
Stats
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N/A
Issued Date -
May 6, 2010
app pub date -
Feb 27, 2008
filing date -
Mar 5, 2007
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
Brain-localizing polypeptides carrying a reactive group for linking to a molecule that does not have brain-localizing activity were successfully produced by introducing at least two lysine residues into cyclized polypeptides having a brain-localizing motif sequence. These polypeptides have improved metabolic stability compared to conventional brain-localizing polypeptides, and can efficiently translocate desired molecules into the brain.
First Claim
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Family

- 15 United States
- 10 France
- 8 Japan
- 7 China
- 5 Korea
- 2 Other
Patent Owner(s)
Patent Owner | Address | |
---|---|---|
ACTGEN INC | 15-502 AKAHO KOMAGANE-SHI NAGANO |
International Classification(s)

- 2008 Application Filing Year
- A61K Class
- 9711 Applications Filed
- 5862 Patents Issued To-Date
- 60.37 % Issued To-Date
Inventor(s)
Inventor Name | Address | # of filed Patents | Total Citations |
---|---|---|---|
Hara, Hirotaka | Aichi, JP | 41 | 373 |
# of filed Patents : 41 Total Citations : 373 | |||
Haradahira, Terushi | Chiba, JP | 4 | 64 |
# of filed Patents : 4 Total Citations : 64 | |||
Higuchi, Makoto | Chiba, JP | 30 | 84 |
# of filed Patents : 30 Total Citations : 84 | |||
Ki, Hin | Chiba, JP | 1 | 1 |
# of filed Patents : 1 Total Citations : 1 | |||
Nakajo, Tomohiro | Saitama, JP | 1 | 1 |
# of filed Patents : 1 Total Citations : 1 | |||
Sawada, Makoto | Aichi, JP | 109 | 555 |
# of filed Patents : 109 Total Citations : 555 | |||
Suhara, Tetsuya | Chiba, JP | 17 | 23 |
# of filed Patents : 17 Total Citations : 23 | |||
Suzuki, Hiromi | Aichi, JP | 62 | 936 |
# of filed Patents : 62 Total Citations : 936 | |||
Yamamoto, Kazumasa | Aichi, JP | 18 | 241 |
# of filed Patents : 18 Total Citations : 241 |
Cited Art Landscape
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Patent Citation Ranking
- 1 Citation Count
- A61K Class
- 11.97 % this patent is cited more than
- 15 Age
Forward Cite Landscape
- No Forward Cites to Display

Maintenance Fees
Fee | Large entity fee | small entity fee | micro entity fee | due date |
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Fee | Large entity fee | small entity fee | micro entity fee |
---|---|---|---|
Surcharge after expiration - Late payment is unavoidable | $700.00 | $350.00 | $175.00 |
Surcharge after expiration - Late payment is unintentional | $1,640.00 | $820.00 | $410.00 |
Full Text

Legal Events
Date | Code | Event | Description |
---|---|---|---|
Aug 27, 2012 | STCH | INFORMATION ON STATUS: PATENT DISCONTINUATION | free format text: PATENT EXPIRED DUE TO NONPAYMENT OF MAINTENANCE FEES UNDER 37 CFR 1.362 |
Jul 29, 2012 | FP | LAPSED DUE TO FAILURE TO PAY MAINTENANCE FEE | Effective Date: Jul 29, 2012 |
Jul 29, 2012 | LAPS | LAPSE FOR FAILURE TO PAY MAINTENANCE FEES | |
Mar 12, 2012 | REMI | MAINTENANCE FEE REMINDER MAILED | |
Jul 01, 2010 | AS | ASSIGNMENT | free format text: MERGER;ASSIGNOR:LUK LAMELLEN UND KUPPLUNGSBAU BETEILIGUNGS KG;REEL/FRAME:027781/0207 Owner name: LUK VERMOEGENSVERWALTUNGSGESELLSCHAFT MBH, GERMANY Effective Date: Jul 01, 2010 |
Jul 29, 2008 | I | Issuance | |
Mar 16, 2006 | P | Published | |
Oct 10, 2005 | AS | ASSIGNMENT | free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:KREMER, EUGEN;REEL/FRAME:017192/0018 Owner name: LUK LAMELLEN UND KUPPLUNGSBAU BETEILIGUNGS KG, GER Effective Date: Oct 10, 2005 |
Sep 09, 2005 | F | Filing | |
Sep 11, 2004 | PD | Priority Date |

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