Altered Immunogenic Landscape in HIV-1 Envelope Proteins
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United States of America Patent
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Issued Date -
Apr 29, 2010
app pub date -
Sep 3, 2009
filing date -
Sep 3, 2008
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Abandoned
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Abstract
The present invention provides compositions and methods useful in the prevention and treatment of HIV-1 infection in a host subject. High affinity binding of an allosteric dual antagonist to HIV-1 gp120 induces a conformational change in the gp 120 protein that traps the gp 120 protein in a three-dimensional structure that suppresses its function and exposes novel antigenic epitopes to host immune surveillance.
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