CLEAVAGE OF BIP BY SUBTILASE CYTOTOXIN

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United States of America Patent

APP PUB NO 20100104550A1
SERIAL NO

12376021

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Abstract

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Cleavage of BIP (Immunoglobulin binding protein) by subtilase toxin and its application to inhibiting growth of or killing of cells. This has application to treatment of cancers and to conformational diseases and in particular to conformational diseases involving BiP that are influenced by cleavage by the subtilase cytotoxin. The invention also relates to subtilase toxin molecules specifically targeting proliferating cells, in particular tumor cells, or cells expressing a vascular endothelial growth factor receptor.

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Patent Owner(s)

Patent OwnerAddress
ADELAIDE RESEARCH AND INNOVATIONADELAIDE SA 5000

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Backer, Joseph M Sandy Hook, US 13 254
Backer, Marina V Sandy Hook, US 7 122
Paton, Adrienne Webster South Australia, AU 5 4
Paton, James Cleland South Australia, AU 12 18

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