MONOCLONAL ANTIBODY DIRECTED AGAINST THE HUMAN LDL RECEPTOR
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United States of America Patent
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Issued Date -
Apr 22, 2010
app pub date -
Dec 28, 2007
filing date -
Dec 29, 2006
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Abstract
The invention relates to a monoclonal antibody directed against the human LDL (Low Density Lipoprotein) receptor, in which the variable region of each of the light chains is coded by the murine nucleic acid sequence SEQ ID NO: 5, the variable region of each of the heavy chains is coded by the murine nucleic acid sequence SEQ ID NO: 7, or by nucleic acid sequences having a sufficient homology with the sequences SEQ ID NO: 5 and SEQ ID NO: 7 so that the nature and the affinity of the bond between the antibody and its antigene are not modified, while the constant regions of the light chains and the heavy chains thereof are constant regions from a non-murine species.
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