SCREENING FOR BONE ANABOLIC FACTORS
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United States of America Patent
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Issued Date -
Apr 15, 2010
app pub date -
Apr 14, 2008
filing date -
Apr 16, 2007
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Abstract
A method for screening for modulators of the secretion by an osteoclast of a wnt or a wnt signal enhancer comprises exposing osteoclasts in culture to a compound to be screened, exposing a wnt sensitive detection system to conditioned medium from said osteoclast culture, and determining whether a wnt signal is present in said medium by assaying for wnt mediated activation of bone formation by osteoblasts or by wnt mediated activation of LRP5 and or LPR6 signalling in a cell by detection of β catenin or detection of translocation of disheveled, axin, or Frat1 to the cell membrane of said cell.
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