MICROSPHERES FOR THE SUSTAINED RELEASE OF OCTREOTIDE WITH A LOW INITIAL BURST
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United States of America Patent
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Issued Date -
Apr 8, 2010
app pub date -
Oct 6, 2008
filing date -
Oct 6, 2008
priority date (Note) -
Abandoned
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Abstract
This disclosure features microspheres and a method of making them. The microspheres are for sustained release of an octreotide compound with a low initial burst, comprising a poly(D,L-lactide-co-glycolide) polymer matrix and an octreotide compound dispersed in the polymer matrix. The microspheres release less than 1% of a total amount of the octreotide compound within 1 hour at 37° C. and pH 7.4.
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