DIVALENT METAL-ION LOADED NANO-TRANSPORT SYSTEM HAVING A DENDRITIC ARCHITECTURE USEFUL FOR THERAPY
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United States of America Patent
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Issued Date -
Apr 1, 2010
app pub date -
Feb 15, 2008
filing date -
Feb 16, 2007
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Abandoned
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Abstract
Described is the use of a nanocarrier having a dendritic structure which is composed of a dendritic core and at least one shell for the non-covalent encapsulation and/or transport of divalent metal-ions, preferably Cu-ions or Zn(II) -ions. Also described is a pharmaceutical composition containing such nanocarrier complexed divalent metal-ions in a non-covalent encapsulated form. Finally several therapeutic uses of such a nanocarrier divalent metal-ion complex are described, for example for slowing down ageing or for the treatment of Cu-ion transport disorders like Alzheimer's disease (AD) or Menkes disease.
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