MUTANT POLYPEPTIDE HAVING EFFECTOR FUNCTION
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United States of America Patent
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Issued Date -
Apr 1, 2010
app pub date -
Apr 12, 2007
filing date -
Apr 14, 2006
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Abandoned
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Abstract
Mutant polypeptides of the present invention contain an Fc region in which a cysteine residue is substituted for the second amino acid from the glycosylation site to the N terminal side in the Fc region. The Fc region is preferably a human IgG Fc region. The mutant polypeptides of the present invention may also contain an N-linked sugar chain at the glycosylation site in Fc region. Furthermore, a polypeptide domain other than the Fc region of the mutant polypeptides of the present invention may be a polypeptide molecule that recognizes a human cell surface molecule.
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