Animal model exhibiting cancer, pulmonary emphysema and cardiomyopathy
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United States of America Patent
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app pub date -
Jan 26, 2009
filing date -
Aug 14, 2001
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Abstract
A transgenic mouse model for colorectal cancer, pulmonary emphysema or cardiomyopathy comprises a transgenic mouse that produces suboptimal levels of latent transforming growth factor β binding protein 4 (LTBP-4). The transgenic mouse includes a mutation resulting in homozygous disruption of both endogenous alleles of a gene encoding LTBP-4, and develops colorectal cancer, pulmonary emphysema or cardiomyopathy.
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