METHOD FOR SUSTAINEDLY RELEASING BIOACTIVE PEPTIDES AND APPLICATION THEREOF
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United States of America Patent
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Issued Date -
Mar 25, 2010
app pub date -
Sep 23, 2008
filing date -
Sep 23, 2008
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Abstract
The present invention provides a method for sustainedly releasing bioactive peptide, comprising a bioactive peptide conjugated to a serum albumin binding peptide through a molecular linker so as to form a fusion polypeptide, in which the molecular linker is sensitive to plasma environment; and transferring the fusion polypeptide to a host, whereby plasma proteinase or alkaline pH of blood in the host can cleave the molecular linker to release the bioactive peptide therein. The fusion polypeptide is sensitive to plasma environment and the sustained release of bioactive peptide ensures the activity of released peptide, resulting in an increased circulation half-life in the host. The present invention also provides a method for using the fusion polypeptide drug as described above to treat human type 2 diabetes, human osteoporosis or cancer.
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