CYCLIC SULFONIUM SALT, METHOD FOR PRODUCTION OF CYCLIC SULFONIUM SALT, AND GLYCOSIDASE INHIBITOR
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United States of America Patent
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Issued Date -
Mar 11, 2010
app pub date -
Jan 4, 2008
filing date -
Jan 3, 2007
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Abandoned
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Abstract
Disclosed are: kotalanol which has an inhibitory activity on a glucosidase; a method for producing kotalanol or a cyclic sulfonium salt which is an analogue to kotalanol by an organic synthesis technique; a cyclic sulfonium salt produced by the method; a glucosidase inhibitor comprising the compound; an anti-diabetic agent or an anti-diabetic food comprising the glucosidase inhibitor. A sulfonium compound including kotalanol can be produced by coupling a thio-sugar synthesized from D-xylose (e.g., a compound having a cyclic structure composed of 4 carbon atoms and one sulfur atom, such as 1,4-dideoxy-1,4-epithio-D-arabinitol) with a heptitol cyclic sulfate ester having a protected hydroxyl group and synthesized from a pentose (D-xylose, D-ribose, D-arabinose, D-lyxose, L-xylose, L-ribose, L-arabinose or L-lyxose) to produce a cyclic sulfonium salt having a protected hydroxyl group, and then deprotecting the hydroxyl group.
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