RECOMBINANT EXPRESSED BIOADSORBABLE POLYHYDROXYALKANOATE MONOFILAMENT AND MULTI-FILAMENTS SELF-RETAINING SUTURES

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United States of America Patent

SERIAL NO

12472219

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Abstract

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The present invention provides polymers made by genetically engineering microorganisms for making a self-retaining suture. In an embodiment of the present invention the genetically engineering microorganisms synthesize polyhydroxyalkanoate (PHA) polymers. In an alternate embodiment of the invention, the genetically engineering microorganisms synthesize polybetahydroxybutyrate (PHB) polymers. In an alternative embodiment of the invention, the self-retaining sutures can be made from a copolymer such as polyhydroxybutyratevalerate (PHBV), where the genetically engineering microorganisms produces PHA polymers as the monofilament base material and a different genetically engineering microorganisms produces polyhydroxybutyratevalerate (PHBV) polymers. In various embodiments of the invention, recombinant expressed self-retaining suture materials have a melting point in the range from between approximately 40° C. to approximately 180° C. In various embodiments of the invention, recombinant expressed self-retaining suture materials have extension-to-break strength of between approximately 8% and approximately 42%.

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Patent Owner(s)

Patent OwnerAddress
TEPHA INC99 HAYDEN AVENUE SUITE 360 LEXINGTON MA 02421

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
D'Agostino, William L Hamden, US 26 7914
Rizk, Said Salem, US 116 1867

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