SUBSTITUTED LACTAMS AS INHIBITORS OF ABETA PROTEIN PRODUCTION
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United States of America Patent
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app pub date -
Sep 22, 2009
filing date -
Apr 11, 2000
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Abstract
This invention relates to novel lactams of Formula (I):having drug and bio-affecting properties, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of Aβ-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to β-amyloid production such as Alzheimer's disease and Down's Syndrome.
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