Transgenic non-human animal models of apoptosis-mediated conditions
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United States of America Patent
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Issued Date -
Feb 25, 2010
app pub date -
Aug 22, 2008
filing date -
Aug 22, 2008
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Abandoned
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Abstract
A transgenic non-human animal whose genome comprises a stable integration of a transgene that encodes at least one Fas-ligand protein operably-linked to a tetracycline-inducible promoter includes cells that express the transgene and undergo apoptosis. The transgenic non-human animal can be used to screen for compounds that inhibit apoptosis and to identify cells that are capable of differentiating in vivo.
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