Novel tyrosinase-specific anti-gene oligonucleotides as depigmenting agents
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United States of America Patent
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Issued Date -
Feb 25, 2010
app pub date -
Sep 1, 2006
filing date -
Sep 1, 2005
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Abstract
The present invention relates to an anti-gene oligonucleotide which hybridizes specifically with the gene encoding human tyrosinase by Hoogsteen pairing between the complementary bases, said oligonucleotide forming a triple helix structure with the human tyrosinase gene. The invention also relates to the use of said oligonucleotide as a skin-depigmenting or skin-bleaching agent in a cosmetic composition or in a dermatological composition.
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