PROTEIN-BINDING METHOTREXATE DERIVATIVES, AND MEDICAMENTS CONTAINING THE SAME
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United States of America Patent
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Issued Date -
Feb 18, 2010
app pub date -
Jul 25, 2007
filing date -
Jul 28, 2006
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Abstract
The invention relates to methotrexate derivatives which contain a protein-binding group and can be enzymatically cleaved in the body such that the active substance or a low-molecular active substance derivative is released. Also disclosed is a method for producing methotrexate derivatives, the use thereof, and medicaments comprising methotrexate derivative.
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