DRUG DELIVERY COATING FOR USE WITH A MEDICAL DEVICE AND METHODS OF TREATING VASCULAR INJURY
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United States of America Patent
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Issued Date -
Feb 11, 2010
app pub date -
Apr 28, 2006
filing date -
Apr 29, 2005
priority date (Note) -
Abandoned
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Abstract
The present inventions provide various embodiments of medical devices coated with a therapeutic coating comprising a mTOR targeting compound and a calcineurin inhibitor, and methods of applying said coatings. In various aspects, the therapeutic coating comprises a bio-absorbable carrier component at least partially formed of a cellular uptake inhibitor and a cellular uptake enhancer, a mTOR targeting compound and a calcineurin inhibitor. In various aspects, the present invention provides for controlled delivery, which is at least partially characterized by total and relative amounts of a cellular uptake inhibitor and cellular uptake enhancer in a bio-absorbable carrier component.
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