Inhibitors of fatty acid oxidation for prophylaxis and treatment of diseases related to mitochondrial dysfunction
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United States of America Patent
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app pub date -
Jun 29, 2009
filing date -
Oct 26, 2001
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Abstract
Described are a method and a composition for preventing and/or treating a disease related to mitochondrial dysfunction by inhibiting the fatty acid oxidation of one or more cells of an organism. Particularly, the fatty acid oxidation is inhibited by inhibiting the expression and/or activity of the enzyme Carnitin-Palmitoyl-Transferase-1 (CPT-1) by means of an arylalkyl- or arlyoxyalkyl-substitued oxirane carboxylic acid or pharmaceutically acceptable salts and derivatives of the arylalkyl-substituted oxirane carboxylic acid.
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