METHODS FOR DIAGNOSING OSTEOARTHRITIS
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United States of America Patent
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Issued Date -
Feb 4, 2010
app pub date -
Oct 25, 2007
filing date -
Oct 25, 2006
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Abstract
Methods are disclosed for assessing risk of developing osteoarthritis. Said methods comprise determining the cellular localizations, blood or synovial fluid concentrations, sumoylation states and post-translational modifications of pituitary homeobox transcription factor 1 (pitx-1) repressor proteins, identifying mutations in genes which encode said proteins and identifying any mutations or post-translational modifications causing the nuclear accumulation or retention of said proteins. Said proteins include prohibitin (PHB-I), prohibitone (PHB-2) and B cell lymphoma-6 transcriptional repressor interacting co-repressor (BCoR).
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